Why Pfizer (PFE) Stock Is Trending – December 16, 2025
Intraday snapshot (Dec 16 2025, 11:49 AM ET) – Pfizer shares traded around $25.23, down roughly 4.5% from the prior close, with the session range so far at $24.92–$26.50. The decline reflects investor reaction to fresh guidance and recent news around obesity‑drug partnerships.
Big catalysts – Pfizer has vaulted onto Unusual Whales’ most‑searched lists thanks to two major moves: a $10 billion acquisition of obesity‑drug developer Metsera and a $2.1 billion licensing deal with China’s YaoPharma. These deals give Pfizer a foothold in the booming GLP‑1 weight‑loss market but won’t deliver revenue for years, leaving investors debating whether the price was worth it. CEO Albert Bourla has pledged to be a “formidable competitor” in obesity drugs.
Fresh guidance and mixed analyst views – On December 16, Pfizer lowered its 2025 revenue forecast to about $62 billion and issued a tepid 2026 outlook. The news sent the stock down more than 5% intraday and spurred heavy options activity. Analysts remain split: Morgan Stanley trimmed its target to $28 while HSBC lifted its target to $29, reflecting uncertainty around Pfizer’s pipeline and valuation.
Dividend vs. short interest – With a dividend yield near 6.6% and 16 consecutive annual increases, PFE appeals to income investors. Yet short sellers have increased positions by 84% this year, betting that COVID‑19 revenue declines and upcoming patent expirations will pressure earnings.
Bottom line
PFE is trending because it sits at a crossroads: the company is betting big on obesity drugs while its near‑term revenue faces headwinds. The combination of new guidance, divergent analyst calls, high dividend yield, and rising short interest has made Pfizer a popular ticker on Unusual Whales and a volatile trade for investors.
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